SrasV1, Main, Exploration, bibRecord, 000C07

Vanadium: History, chemistry, interactions with α-amino acids and potential therapeutic applications.

Identifieur interne : 000C07 ( Main/Exploration ); précédent : 000C06; suivant : 000C08

Vanadium: History, chemistry, interactions with α-amino acids and potential therapeutic applications.

Auteurs : Edgar Del Carpio [Venezuela] ; Lino Hernández [Venezuela] ; Carlos Ciangherotti [Venezuela] ; Valentina Villalobos Coa [Venezuela] ; Lissette Jiménez [Venezuela] ; Vito Lubes [Venezuela] ; Giuseppe Lubes [Venezuela]

Source :

Coordination chemistry reviews [ 0010-8545 ] ; 2018.

RBID : pubmed:32226092

Abstract

In the last 30 years, since the discovery that vanadium is a cofactor found in certain enzymes of tunicates and possibly in mammals, different vanadium-based drugs have been developed targeting to treat different pathologies. So far, the in vitro studies of the insulin mimetic, antitumor and antiparasitic activity of certain compounds of vanadium have resulted in a great boom of its inorganic and bioinorganic chemistry. Chemical speciation studies of vanadium with amino acids under controlled conditions or, even in blood plasma, are essential for the understanding of the biotransformation of e.g. vanadium antidiabetic complexes at the physiological level, providing clues of their mechanism of action. The present article carries out a bibliographical research emphaticizing the chemical speciation of the vanadium with different amino acids and reviewing also some other important aspects such as its chemistry and therapeutical applications of several vanadium complexes.

DOI: 10.1016/j.ccr.2018.06.002
PubMed: 32226092

Affiliations:

Venezuela

Le document en format XML

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<author><name sortKey="Lubes, Giuseppe" sort="Lubes, Giuseppe" uniqKey="Lubes G" first="Giuseppe" last="Lubes">Giuseppe Lubes</name>
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<front><div type="abstract" xml:lang="en">In the last 30 years, since the discovery that vanadium is a cofactor found in certain enzymes of tunicates and possibly in mammals, different vanadium-based drugs have been developed targeting to treat different pathologies. So far, the <i>in vitro</i>
 studies of the insulin mimetic, antitumor and antiparasitic activity of certain compounds of vanadium have resulted in a great boom of its inorganic and bioinorganic chemistry. Chemical speciation studies of vanadium with amino acids under controlled conditions or, even in blood plasma, are essential for the understanding of the biotransformation of e.g. vanadium antidiabetic complexes at the physiological level, providing clues of their mechanism of action. The present article carries out a bibliographical research emphaticizing the chemical speciation of the vanadium with different amino acids and reviewing also some other important aspects such as its chemistry and therapeutical applications of several vanadium complexes.</div>
</front>
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<tree><country name="Venezuela"><noRegion><name sortKey="Del Carpio, Edgar" sort="Del Carpio, Edgar" uniqKey="Del Carpio E" first="Edgar" last="Del Carpio">Edgar Del Carpio</name>
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<name sortKey="Ciangherotti, Carlos" sort="Ciangherotti, Carlos" uniqKey="Ciangherotti C" first="Carlos" last="Ciangherotti">Carlos Ciangherotti</name>
<name sortKey="Hernandez, Lino" sort="Hernandez, Lino" uniqKey="Hernandez L" first="Lino" last="Hernández">Lino Hernández</name>
<name sortKey="Jimenez, Lissette" sort="Jimenez, Lissette" uniqKey="Jimenez L" first="Lissette" last="Jiménez">Lissette Jiménez</name>
<name sortKey="Lubes, Giuseppe" sort="Lubes, Giuseppe" uniqKey="Lubes G" first="Giuseppe" last="Lubes">Giuseppe Lubes</name>
<name sortKey="Lubes, Vito" sort="Lubes, Vito" uniqKey="Lubes V" first="Vito" last="Lubes">Vito Lubes</name>
<name sortKey="Villalobos Coa, Valentina" sort="Villalobos Coa, Valentina" uniqKey="Villalobos Coa V" first="Valentina" last="Villalobos Coa">Valentina Villalobos Coa</name>
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Vanadium: History, chemistry, interactions with α-amino acids and potential therapeutic applications.

Vanadium: History, chemistry, interactions with α-amino acids and potential therapeutic applications.

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